Acupuncture & Cancer

Acupuncture, an ancient medical practice rooted in traditional Chinese medicine, has steadily gained recognition in the realm of cancer treatment. Over the years, it has emerged as a complementary therapy that many cancer patients turn to in order to alleviate treatment-related symptoms and improve their quality of life. While acupuncture is not a cure for cancer, it has shown promise in managing various physical and emotional side effects.

Cancer treatment often involves surgery, chemotherapy, radiation, or a combination of these therapies. These interventions, while essential and necessary for eradicating cancer cells, can cause a range of discomforting symptoms. Nausea, fatigue, neuropathy, pain, anxiety, and depression are just a few examples of the challenges that cancer patients frequently endure along their journey. This is where acupuncture steps in as a potential solution.

Acupuncture treatment can help reduce

  • Pain

  • Fatigue

  • Hot flashes

It can also help improve

  • Sleep

  • Dry mouth

  • Nausea and vomiting

In Chinese Medicine, acupuncture points along channels or meridians help energy flow. Pain and disease occur with blocked Qi. Acupuncture treats by balancing Qi and increasing feel-good chemicals in the brain. Hair-thin needles stimulate acupoints to restore balance and promote healing. Studies show acupuncture relieves pain, reduces stress, anxiety, and depression. It improves sleep and blood flow, reduces inflammation, and affects the brain and body. Certain acupuncture points help with dry mouth and nerve pain. Research explores acupuncture's mechanisms for better treatments.

The Significance of Acupuncture

As the field of oncology continues to progress, the exploration of complementary therapies becomes increasingly important. Among these therapies, acupuncture shines as a potential ray of hope for cancer patients, offering a more holistic approach to their medical journey and alleviating treatment-related symptoms while supporting overall well-being.
Acupuncture is a therapeutic component deeply rooted in Traditional Chinese Medicine. This ancient practice involves the insertion of thin needles into specific points on the body. By stimulating these points, acupuncture aims to promote the flow and balance of internal energy, known as Qi.

Clinical trials have lent significant support to the use of acupuncture in the relief of various cancer treatment-related symptoms. Pain, a common and distressing side effect of cancer therapies, has been shown to benefit from acupuncture. Additionally, acupuncture has demonstrated efficacy in reducing treatment-induced nausea and vomiting, dry mouth, fatigue, hot flashes, and nerve pain.
One particular aspect that distinguishes acupuncture is its potential for long-lasting effects. Studies have indicated that the benefits of acupuncture endure well beyond the actual treatment period. This means that patients can experience relief from symptoms even after the acupuncture sessions have ended, providing a valuable ongoing support system in their journey toward recovery.

 
By adding acupuncture to oncology care, healthcare providers offer cancer patients a holistic and diverse treatment, benefitting their well-being. This therapy targets symptoms and supports their overall health, including physical, emotional, and mental aspects.
 

As the advancements in oncology continue, the significance of acupuncture in cancer care cannot be understated. Through its ability to alleviate treatment-related symptoms and enhance the overall quality of life for patients, acupuncture emerges as an invaluable component of the evolving landscape of cancer treatment. By embracing this ancient practice, healthcare practitioners open new avenues of hope and healing for those battling cancer.

Research for Acupuncture

According to Traditional Chinese Medicine (TCM), acupuncture points are specific areas located along channels or meridians. In this network, called Qi (pronounced chee), which means energy, flows and connects different parts of the body. When Qi becomes stagnant, it is believed to cause pain and disease symptoms. Acupuncture treatments aim to promote the flow of Qi and relieve these symptoms. Additionally, acupuncture is known to stimulate the release of natural pain-relieving substances called endogenous opioids. There are some animal studies have shown that acupuncture induces analgesia through different opioid receptors.

Acupuncture has multiple benefits for the body. It can improve sleep, reduce pain, and enhance nerve signals. By affecting specific receptors in the body, acupuncture can alleviate both sleep disturbances and pain. Additionally, it has been shown to have a positive impact on patients with peripheral neuropathy, enhancing their nerve signals.
Acupuncture has been found to have an influence on various areas of the brain, including those associated with senses, emotions, and thinking.

Research from clinical trials and with functional MRI tests. Results of these studies show acupuncture is safe and effective for treating:

  • pain

  • fatigue

  • insomnia

  • hot flashes

  • dry mouth

  • constipation

  • neuropathy

  • nausea and vomiting

The Journal of Clinical Oncology and the National Comprehensive Cancer Network recommend acupuncture for cancer pain, fatigue, and hot flashes . Also the Society for Integrative Oncology have released guidelines from to recommend acupuncture for joint pain, musculoskeletal pain, and general cancer pain , and for anxiety.

There is a growing body of evidence that show that acupuncture helps manage :

 
  • cancer pain 

  • including persistent neuropathy

  • joint pain 

  • can decrease fatigue

  • help with pain medication use

  • help with sleep

  • cognitive function

  • health-related quality of life

  • nausea and vomiting

  • hot flashes

  • dry mouth from radiotherapy

  • reduce lymphedema

  • postoperative bowel obstruction

 

Cancer patients also struggle with debilitating fatigue, which can greatly impact their day-to-day functioning. In this regard, acupuncture has demonstrated the potential to alleviate fatigue and improve overall energy levels. By tapping into the body's natural resources, acupuncture sessions can enhance vitality and restore a sense of normalcy to a cancer patient's life. Beyond physical symptoms, cancer often takes a toll on the emotional well-being of patients. Anxiety, depression, and sleep disturbances are common psychological issues that cancer patients grapple with. In this aspect, acupuncture has shown promise in reducing anxiety and depression symptoms and improving sleep quality. By promoting relaxation, acupuncture can provide much-needed emotional support during a challenging time.

Safety of Acupuncture

While acupuncture is generally safe, it is crucial for cancer patients to seek acupuncture treatments from qualified and certified practitioners who have experience working with oncology patients. Open communication between patients, their oncologists, and acupuncturists is vital to ensuring the integration of acupuncture into the individual's comprehensive cancer care plan.

It's important to note that although acupuncture has shown positive results in managing cancer-related symptoms, it should not be seen as a standalone treatment or a substitute for conventional cancer therapies. Instead, it should be viewed as a complementary therapy that can work in conjunction with standard care to enhance the overall well-being of cancer patients.

Research Articles

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  2. National Comprehensive Cancer Network. NCCN Guidelines: Supportive Care.

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  6. Mao JJ, Liou KT, Baser RE, et al. Effectiveness of Electroacupuncture or Auricular Acupuncture vs Usual Care for Chronic Musculoskeletal Pain Among Cancer Survivors: The PEACE Randomized Clinical Trial. JAMA Oncol. May 1 2021;7(5):720-727.

  7. Yang M, Liou KT, Garland SN, et al. Acupuncture versus cognitive behavioral therapy for pain among cancer survivors with insomnia: an exploratory analysis of a randomized clinical trial. NPJ Breast Cancer. Nov 30 2021;7(1):148.

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  9. Bao T, Seidman AD, Piulson L, et al. A phase IIA trial of acupuncture to reduce chemotherapy-induced peripheral neuropathy severity during neoadjuvant or adjuvant weekly paclitaxel chemotherapy in breast cancer patients. Eur J Cancer. Sep 2018;101:12-19.

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  22. Deng G, Giralt S, Chung DJ, et al. Acupuncture for reduction of symptom burden in multiple myeloma patients undergoing autologous hematopoietic stem cell transplantation: a randomized sham-controlled trial. Support Care Cancer. Feb 2018;26(2):657-665.

  23. He Y, Guo X, May BH, et al. Clinical Evidence for Association of Acupuncture and Acupressure With Improved Cancer Pain: A Systematic Review and Meta-Analysis. JAMA Oncol. Feb 1 2020;6(2):271-278.

  24. Deng G, Giralt S, Chung DJ, et al. Reduction of Opioid Use by Acupuncture in Patients Undergoing Hematopoietic Stem Cell Transplantation: Secondary Analysis of a Randomized, Sham-Controlled Trial. Pain Med. Mar 1 2020;21(3):636-642.

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  29. Zhu YJ, Wu XY, Wang W, et al. Acupuncture for Quality of Life in Gastric Cancer Patients Undergoing Adjuvant Chemotherapy. J Pain Symptom Manage. Feb 2022;63(2):210-220.

  30. Rithirangsriroj K, Manchana T, Akkayagorn L. Efficacy of acupuncture in prevention of delayed chemotherapy induced nausea and vomiting in gynecologic cancer patients. Gynecol Oncol. Jan 2015;136(1):82-86.

  31. Lee A, Fan LT. Stimulation of the wrist acupuncture point P6 for preventing postoperative nausea and vomiting. Cochrane Database Syst Rev. Apr 15 2009(2):Cd003281.

  32. Garcia MK, McQuade J, Haddad R, et al. Systematic review of acupuncture in cancer care: a synthesis of the evidence. J Clin Oncol. Mar 1 2013;31(7):952-960.

  33. Walker EM, Rodriguez AI, Kohn B, et al. Acupuncture versus venlafaxine for the management of vasomotor symptoms in patients with hormone receptor-positive breast cancer: a randomized controlled trial. J Clin Oncol. Feb 1 2010;28(4):634-640.

  34. Beer TM, Benavides M, Emmons SL, et al. Acupuncture for hot flashes in patients with prostate cancer. Urology. Nov 2010;76(5):1182-1188.

  35. Mao JJ, Bowman MA, Xie SX, et al. Electroacupuncture Versus Gabapentin for Hot Flashes Among Breast Cancer Survivors: A Randomized Placebo-Controlled Trial. J Clin Oncol. Nov 1 2015;33(31):3615-3620.

  36. Lesi G, Razzini G, Musti MA, et al. Acupuncture As an Integrative Approach for the Treatment of Hot Flashes in Women With Breast Cancer: A Prospective Multicenter Randomized Controlled Trial (AcCliMaT). J Clin Oncol. May 20 2016;34(15):1795-1802.

  37. Meng Z, Garcia MK, Hu C, et al. Randomized controlled trial of acupuncture for prevention of radiation-induced xerostomia among patients with nasopharyngeal carcinoma. Cancer. Jul 1 2012;118(13):3337-3344.

  38. Garcia MK, Chiang JS, Cohen L, et al. Acupuncture for radiation-induced xerostomia in patients with cancer: a pilot study. Head Neck. Oct 2009;31(10):1360-1368.

  39. Wong RK, James JL, Sagar S, et al. Phase 2 results from Radiation Therapy Oncology Group Study 0537: a phase 2/3 study comparing acupuncture-like transcutaneous electrical nerve stimulation versus pilocarpine in treating early radiation-induced xerostomia. Cancer. Sep 1 2012;118(17):4244-4252.

  40. Simcock R, Fallowfield L, Monson K, et al. ARIX: a randomised trial of acupuncture v oral care sessions in patients with chronic xerostomia following treatment of head and neck cancer. Ann Oncol. Mar 2013;24(3):776-783.

  41. Garcia MK, Meng Z, Rosenthal DI, et al. Effect of True and Sham Acupuncture on Radiation-Induced Xerostomia Among Patients With Head and Neck Cancer: A Randomized Clinical Trial. JAMA Netw Open. Dec 2 2019;2(12):e1916910.

  42. Bao T, Iris Zhi W, Vertosick EA, et al. Acupuncture for breast cancer-related lymphedema: a randomized controlled trial. Breast Cancer Res Treat. Jul 2018;170(1):77-87.

  43. Cassileth BR, Van Zee KJ, Yeung KS, et al. Acupuncture in the treatment of upper-limb lymphedema: results of a pilot study. Cancer. Jul 1 2013;119(13):2455-2461.

  44. Deng G, Wong WD, Guillem J, et al. A phase II, randomized, controlled trial of acupuncture for reduction of Postcolectomy Ileus. Ann Surg Oncol. Apr 2013;20(4):1164-1169.

  45. Ng SSM, Leung WW, Mak TWC, et al. Electroacupuncture reduces duration of postoperative ileus after laparoscopic surgery for colorectal cancer. Gastroenterology. Feb 2013;144(2):307-313.e301.

  46. Meng X, Zhang Y, Li A, et al. The effects of opioid receptor antagonists on electroacupuncture-produced anti-allodynia/hyperalgesia in rats with paclitaxel-evoked peripheral neuropathy. Brain Res. Sep 26 2011;1414:58-65.

  47. Pomeranz B, Warma N. Electroacupuncture suppression of a nociceptive reflex is potentiated by two repeated electroacupuncture treatments: the first opioid effect potentiates a second non-opioid effect. Brain Res. Jun 14 1988;452(1-2):232-236.

  48. Peets JM, Pomeranz B. CXBK mice deficient in opiate receptors show poor electroacupuncture analgesia. Nature. Jun 22 1978;273(5664):675-676.

  49. Liou KT, Garland SN, Li QS, et al. Effects of acupuncture versus cognitive behavioral therapy on brain-derived neurotrophic factor in cancer survivors with insomnia: an exploratory analysis.Acupunct Med. Dec 2021;39(6):637-645.

  50. Harris RE, Zubieta JK, Scott DJ, et al. Traditional Chinese acupuncture and placebo (sham) acupuncture are differentiated by their effects on mu-opioid receptors (MORs). Neuroimage. Sep 2009;47(3):1077-1085.

  51. Schröder S, Liepert J, Remppis A, et al. Acupuncture treatment improves nerve conduction in peripheral neuropathy. Eur J Neurol. Mar 2007;14(3):276-281.

  52. Yoo SS, Teh EK, Blinder RA, et al. Modulation of cerebellar activities by acupuncture stimulation: evidence from fMRI study. Neuroimage. Jun 2004;22(2):932-940.

  53. Deng G, Hou BL, Holodny AI, et al. Functional magnetic resonance imaging (fMRI) changes and saliva production associated with acupuncture at LI-2 acupuncture point: a randomized controlled study.BMC Complement Altern Med. Jul 7 2008;8:37.

  54. Huang W, Pach D, Napadow V, et al. Characterizing acupuncture stimuli using brain imaging with FMRI—a systematic review and meta-analysis of the literature. PLoS One. 2012;7(4):e32960.

  55. Romero SAD, Li QS, Orlow I, et al. Genetic predictors to acupuncture response for hot flashes: an exploratory study of breast cancer survivors. Menopause. Aug 2020;27(8):913-917.

  56. Witt CM, Vertosick EA, Foster NE, et al. The Effect of Patient Characteristics on Acupuncture Treatment Outcomes: An Individual Patient Data Meta-Analysis of 20,827 Chronic Pain Patients in Randomized Controlled Trials. Clin J Pain. May 2019;35(5):428-434.

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  58. Melchart D, Weidenhammer W, Streng A, et al. Prospective investigation of adverse effects of acupuncture in 97 733 patients. Arch Intern Med. Jan 12 2004;164(1):104-105.

  59. He W, Zhao X, Li Y, et al. Adverse events following acupuncture: a systematic review of the Chinese literature for the years 1956-2010. J Altern Complement Med. Oct 2012;18(10):892-901.

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